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KMID : 0604520210470030255
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Journal of the Society of Cosmetic Scientists of Korea
2021 Volume.47 No. 3 p.255 ~ p.263
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Fermented Jeju Soybean Extract Promotes Hair Growth in Human Hair Follicle Organ Culture and Clinical Trial
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Lee Yong-Hee
Shin Seung-Hyun
Kim Se-Hyun
Jeong Gyu-Sang
Hong Min-Jung
Park Hyeok-Gon
Kim Seung-Hun
Kim Eun-Joo
Kang Young-Gyu
Park Byung-Cheol
Park Won-Seok
Kim Su-Na
Kim Hyoung-June
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Abstract
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Soybean extract is known to play an important role in preventing and treating diseases associated with aging, cancer, obesity, and cardiovascular disease. A recent has revealed that soybean extract has a potent effect on hair growth in in vitro, in vivo, and clinical studies. Recently, it has been reported that their fermented extracts exhibit numerous and high efficacy, as compared to general extracts. However, the underlying mechanisms that induce hair growth after using fermented soybean extract are not well understood. The present study aimed to determine the effects of fermented Jeju soybean (FJS) extract on hair growth, with a focus on the underlying mechanisms similar to those of minoxidil. We conducted in vitro and ex vivo investigations and clinical studies. FJS extract enhanced dermal papilla cell proliferation, VEGF levels, and potassium channel opening. Moreover, it promoted human hair follicle elongation. These effects were comprehensively demonstrated in the clinical results, in which FJS extract-containing shampoo improved hair density after 24 weeks of utilization. Collectively, the results of this study demonstrate that FJS extract promotes hair growth and inhibits hair loss through a mechanism similar to that of minoxidil in hair follicles.
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KEYWORD
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fermented Jeju soybean extract, hair growth, human dermal papilla cells, hair follicle, minoxidil
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